Successful treatment of D-penicillamine-induced breast gigantism with danazol.

Lipodermatosclerosis: successful treatment with danazol.

Sir, Lipodermatosclerosis (LDS), also reported as liposclerosis, hypodermatitis sclerodermaformis, sclerosing panniculitis, pseudoscleroderma, indurated cellulitis, stasis panniculitis and chronic cellulitis, is characterized by a scleroderma-like induration of the skin and a typical ‘inverted champagne bottle’ sign. Although considerable progress has been made in understanding the pathophysiol...

D penicillamine and breast enlargement.

D-Penicillamine induced myasthenia gravis.

Myasthenia gravis is a disorder of impaired neuromuscular transmission resulting in weakness and abnormal fatigability on exertion, improved by anti-acetyl cholinesterase drugs. A number of drugs are known to exacerbate myasthenia gravis or interfere with neuromuscular transmission. We report a case of D-penicillamine induced myasthenia gravis who developed ptosis, diplopia and easy fatigabilit...

D-penicillamine Induced Myasthenia Gravis

Rheumatoid arthritis can be a very mutilating disease and, as a result, the likelihood of patients with rheumatoid arthritis requiring surgery and anaesthesia is increased. D-penicillamine (D-Pen) has been used in the treatment of rheumatoid arthritis and Wilson's disease since the early 1960s. Its true mode of action is unknown, but it appears to modify the immune response. Treatment with D-Pe...

Polymyositis complicating D-penicillamine treatment.

Although there is good evidence that D-penicillamine can induce polymyositis, the exact pathogenic mechanism remains unclear. We report two patients with psoriatic arthritis and primary biliary cirrhosis respectively, who developed polymyositis while receiving D-penicillamine treatment for their primary diseases. Whether D-penicillamine treatment was the sole cause of polymyositis or acted as a...